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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TLK2
All Species:
6.06
Human Site:
S377
Identified Species:
13.33
UniProt:
Q86UE8
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86UE8
NP_001106178.1
772
87661
S377
A
E
N
E
T
P
S
S
G
N
T
E
L
K
D
Chimpanzee
Pan troglodytes
XP_523598
848
95816
L475
A
E
N
E
T
L
T
L
A
E
Y
H
E
Q
E
Rhesus Macaque
Macaca mulatta
XP_001107302
907
100501
S515
A
E
N
E
T
P
P
S
G
N
T
E
L
K
D
Dog
Lupus familis
XP_548038
918
102784
L545
A
E
N
E
T
L
T
L
A
E
Y
H
E
Q
E
Cat
Felis silvestris
Mouse
Mus musculus
O55047
718
82242
L345
A
E
N
E
T
L
T
L
A
E
Y
H
E
Q
E
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515053
718
81881
K356
H
E
Q
E
E
I
F
K
L
R
L
G
H
L
K
Chicken
Gallus gallus
XP_418070
750
85456
L377
A
E
N
E
T
L
T
L
A
E
Y
H
E
Q
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q1ECX4
697
79286
K343
K
L
R
L
G
H
L
K
K
E
E
A
E
I
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624065
793
90042
A392
S
L
H
N
G
T
E
A
T
F
L
K
P
D
A
Nematode Worm
Caenorhab. elegans
P34314
965
109255
T566
S
N
G
M
Q
P
S
T
S
S
N
T
N
G
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39238
688
78131
D334
L
K
K
R
Q
N
G
D
K
N
D
G
T
D
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.3
82.3
81.2
N.A.
92.4
N.A.
N.A.
68.6
94.1
N.A.
77.9
N.A.
N.A.
47.9
36.5
N.A.
Protein Similarity:
100
88.3
83
81.3
N.A.
92.7
N.A.
N.A.
77.7
95.8
N.A.
83.9
N.A.
N.A.
63.4
50.1
N.A.
P-Site Identity:
100
33.3
93.3
33.3
N.A.
33.3
N.A.
N.A.
13.3
33.3
N.A.
0
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
100
53.3
93.3
53.3
N.A.
53.3
N.A.
N.A.
13.3
53.3
N.A.
0
N.A.
N.A.
26.6
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
35.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
50.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
55
0
0
0
0
0
0
10
37
0
0
10
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
0
10
0
0
19
28
% D
% Glu:
0
64
0
64
10
0
10
0
0
46
10
19
46
0
37
% E
% Phe:
0
0
0
0
0
0
10
0
0
10
0
0
0
0
0
% F
% Gly:
0
0
10
0
19
0
10
0
19
0
0
19
0
10
0
% G
% His:
10
0
10
0
0
10
0
0
0
0
0
37
10
0
0
% H
% Ile:
0
0
0
0
0
10
0
0
0
0
0
0
0
10
0
% I
% Lys:
10
10
10
0
0
0
0
19
19
0
0
10
0
19
10
% K
% Leu:
10
19
0
10
0
37
10
37
10
0
19
0
19
10
0
% L
% Met:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
55
10
0
10
0
0
0
28
10
0
10
0
0
% N
% Pro:
0
0
0
0
0
28
10
0
0
0
0
0
10
0
0
% P
% Gln:
0
0
10
0
19
0
0
0
0
0
0
0
0
37
10
% Q
% Arg:
0
0
10
10
0
0
0
0
0
10
0
0
0
0
0
% R
% Ser:
19
0
0
0
0
0
19
19
10
10
0
0
0
0
0
% S
% Thr:
0
0
0
0
55
10
37
10
10
0
19
10
10
0
10
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
37
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _